| | Sin comenzar | Jue, 18 FEB 2021 |  Olympiacos Piraeus | 18:55 | PSV |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Slavia Praha | 18:55 | Leicester |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  R. Sociedad | 18:55 | Man. Utd |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  FK Krasnodar | 18:55 | Dinamo Zagreb |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Crvena Zvezda | 18:55 | Milan |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Wolfsberger AC | 18:55 | Tottenham Hotspur |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Young Boys | 18:55 | B. Leverkusen |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Dinamo Kiev | 18:55 | Club Brugge |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Sporting Braga | 18:55 | Roma |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Benfica | 21:00 | Arsenal |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Molde FK | 21:00 | Hoffenheim |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Lille | 21:00 | Ajax |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Salzburg | 21:00 | Villarreal |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Antwerp | 21:00 | Rangers FC |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Maccabi Tel Aviv | 21:00 | Shakhtar Donetsk |
|
| | Sin comenzar | Jue, 18 FEB 2021 |  Granada | 21:00 | Napoli |
|
| | Sin comenzar | Mie, 24 FEB 2021 | | Tottenham Hotspur | 18:00 | Wolfsberger AC |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Villarreal | 18:55 | Salzburg |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Rangers FC | 18:55 | Antwerp |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Shakhtar Donetsk | 18:55 | Maccabi Tel Aviv |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Napoli | 18:55 | Granada |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Arsenal | 18:55 | Benfica |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Hoffenheim | 18:55 | Molde FK |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Ajax | 18:55 | Lille |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | B. Leverkusen | 21:00 | Young Boys |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Club Brugge | 21:00 | Dinamo Kiev |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Roma | 21:00 | Sporting Braga |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | PSV | 21:00 | Olympiacos Piraeus |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Man. Utd | 21:00 | R. Sociedad |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Leicester | 21:00 | Slavia Praha |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Dinamo Zagreb | 21:00 | FK Krasnodar |
|
| | Sin comenzar | Jue, 25 FEB 2021 | | Milan | 21:00 | Crvena Zvezda |
|
